Prion protein: structural features and related toxicity
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چکیده
منابع مشابه
Prion protein and Aβ-related synaptic toxicity impairment
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Prion diseases are a family of progressive neurodegenerative disorders, which are fatal in the majority of cases and affect both humans and domestic animals. Prion protein (PrP) (106-126) retains the neurotoxic properties of the entire pathological PrPsc and it is generally used as a reasonable model to study the mechanisms responsible for prion diseases. In our previous studies, we demonstrate...
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Inactivation of mahogunin, an E3 ubiquitin ligase, causes a spongiform encephalopathy resembling prion disease. Chakrabarti and Hegde (2009) now report that prion proteins with aberrant topologies inactivate mahogunin, providing a plausible explanation for certain aspects of prion pathology.
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2013
ISSN: 1672-9145,1745-7270
DOI: 10.1093/abbs/gmt035